亚色影库app

An open access publication of the 亚色影库app & Sciences
Winter 2008

The synthetic future of life

Author
Adrian Woolfson

Adrian Woolfson is CEO of ProteinLogic and teaches medicine at the University of Cambridge. He is the author of 鈥淟ife Without Genes鈥 (2000) and 鈥淎n Intelligent Person's Guide to Genetics鈥 (2004).

In 1540, the German cartographer Sebastian M眉nster published the first accurate map of the African subcontinent. Contrary to the Ptolemaic view鈥 in which Africa, Antarctica, and part of Asia formed a single southern landmass known as Terra Incognito鈥揂frica emerged as a discrete entity in M眉nster鈥檚 representation. Improvements in shipping and navigational techniques, such as triangulation and calculation of longitude, made this map possible. These methods enabled transoceanic voyagers to locate their positions in the absence of landmarks, thus facilitating the exploration of new areas.

M眉nster鈥檚 map was also remarkable for its unusual depiction of Africa鈥檚 wildlife. In his exposition, the Dark Continent teemed not only with conventional creatures like elephants and parrots, but also with mythical ones such as one-eyed Monoculi. The incorporation of imaginary beasts suggests M眉nster鈥檚 anticipation of the synthetic future of life, and indeed his tacit appreciation of the fact that material existence represents only a fraction of natural and artificial possibility.

In the spirit of M眉nster, it is possible to explore the idea of compiling a 鈥榣ibrary of all possible creatures,鈥 a database of DNA sequences of all species, past, present, and future. With this database, we may be able someday to recreate extinct species and even create entirely new ones.

Like M眉nster鈥檚 rudimentary yet imaginative map of Africa, the library鈥揳lso called 鈥楧NA Sequence Space鈥欌揾as a distinct mathematical reality. But in contrast to conventional terrestrial domains, this space is boundless, and so appears on first inspection to defy cartographical representation or even rational exploration. Fortunately, like the corporeal continent that underwrites M眉nster鈥檚 accurate but nevertheless fanciful depiction, at least a small portion of this apparently limitless landscape can be mapped. This is significant, as it is this region that鈥搈uch like the former coalfields of the industrial North England鈥 may most economically yield rich seams of potential life. What we need, though, is a method of predicting the location of these 鈥榗oalfields,鈥 which contain the mathematical structures that are able, in principle, to encode processes of life, as well as the means of deciphering them.

Navigating the contours of this complex, rugged, and tortuous mathematical terrain is onerous and not without its own dangers. But its exploration and eventual mapping will ultimately be far more important than the discovery of the Americas, Antarctica, or any other continent. For within this vast and mostly uncharted Borgian space, all life鈥檚 possibilities may be found: the morphological secrets of existing life as well as of every potential living thing. The moment we complete this project, life will become dissociated from the natural evolutionary processes that have shaped it from its inception. New artificial modes of creation will then supplement, perhaps even supplant, such conventional historical mechanisms.

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